Liver Detoxification Impairment
People with MCS have problems with liver detoxification. This is worsened by adrenal fatigue, food intolerance, and toxicity. Dr Martin Pall has identified 6 gene polymorphisms (adaptions) that affect liver detoxification in people with MCS.
The liver detoxification pathways include: Phase 1: Cytochrome P450, Phase 2: The major pathways include glutathione, sulfate, glycine, and glucuronide conjugations.
The tests used to assess liver detoxification are different to the liver tests normally performed by Doctors when testing for liver damage. They include the:
• Functional Liver Detoxification Profile (FLDP). The Functional Liver Detoxification Profile measures the rate at which Phase 1 and the Phase 2 pathways are detoxifying. This test is very different to the Liver Functioning tests normally performed by GP’s. Specific supplements can be prescribed depending on which pathway or pathways are not functioning very well.
• Detoxi Genomic Profile. This is a more comprehensive test than the FLDP. The Detoxi Genomic Profile identifies genetic variations that may affect your ability to detoxify specific toxins, medications, and even foods. Working with your healthcare provider, you can develop a personalized treatment plan that matches your environment to your genes in order to optimize your health.
To address liver detoxification problems, you need to reduce the demands being placed on your liver, gut, and nervous system. This is best done through stress management and minimization where stress is defined as the TOTAL LOAD being placed on you endogenously (internally) and exogenously (externally). How to do this is outlined in RESHAPE Resources coming soon to MCSLIVING.
Whilst, detoxification and dietary supplements are often recommended and may help some people, for others, symptoms and “sensitisations” may simply be worsened due to the additional stress load being placed on the liver and the nervous system. Supporting the liver through diet can, however, be helpful if your diet is adjusted for pharmacological food intolerance. Low chemical foods high in glycine (e.g., potato, chicken, meat, turkey, cottage cheese, and plain yoghurt) and cysteine (e..g., eggs) are particularly beneficial as these support the production of GLUTATHIONE by the liver – which is the most powerful antioxidant of all. Glutamine is also needed to make glutathione. However, high amounts should not be taken through your diet (in fact, glutamine should be reduced) because people with MCS generally have too much glutamine in their system.
Dr Richard Coleman says, “Glutamate is found in many foods in a natural protein-bound form. It is important in the enjoyable flavour of tomatoes, aged cheese and mushrooms, and most notably found in a Japanese seaweed sauce from which MSG was extracted. Glutamate is the most common neurotransmitter in the brain; that is, it is responsible for transporting chemical signals from neuron to neuron. However, if the level of glutamates is too high, neurons can misfire, causing physical and psychological problems.
Detoxification is a standard recommendation made to many people with MCS. However, detoxification can be dangerous, causing re-injury to the nervous system, liver, and gut. Moreover, intensification of “sensitivities” and symptoms can happen if not done slowly and right by a skilled practitioner. This even goes for FIR Sauna Therapy, which is said to be safe for everyone. This simply is not true as heat and the materials saunas are made of, because they can be very symptom provoking in a lot of people with MCS, particularly when MCS if very severe.
Whilst it is true that sweating out toxins does by-pass an already overworked liver, FIR Sauna Therapy can still be a stressor. All stressors feed into the self-perpetuating toxicity, inflammation, stress (TIS) loop, or for the more scientific amongst us, the NO/OONO disease cycle proposed by Dr Martin Pall.
Whilst enduring some increased stress is absolutely necessary to undo chronic stress adaptions and “sensitizations”, too much, too fast will simply provoke neurogenic inflammation, NMDA over excitability, and glutamine excess, all maintainers of toxicity, sensitizations and nervous system hyper responsiveness to external stimuli (e.g., noise, temperature changes, chemicals, bright flashing lights, multi-activity, and so on).
• Increasing filtered water intake 2-4 liters, no more. Iif drinking large amounts of water,be sure to replenish your minerals. Celtic sea salt is quite safe for this to avoid electrolyte imbalances which worsens dehydration, causing a dry mouth, spasm or cramps and impairs nerve transmission.
• Taking “safe” non-plant based toxin binders (e.g., Zeolites and charcoal tabs). They are best taken 1.5 hrs either side of food and medications so that they do not interfere with absorption and with increased water intake.
• If you are constipated, this can increase toxicity to overcome drink more filtered water and increase your fiber intake by eating low chemical foods high in fiber such as legumes, green peas, cereals. If you want to use a fibre supplement, use Psyllium since it is low in chemicals and much better tolerated by people with “sensitisations” and irritable bowel syndrome (IBS) symptoms. According to Dr. Spiller other fibre supplements make symptoms worse in up to 55% of people with IBS and only help 11% (Guidelines on the irritable bowel syndrome: mechanisms and practical management R Spiller, Q Aziz, […], and P Whorwell http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095723/)
Note: Constipation issues and IBS should become a thing of the past once you transition to a balanced healthy diet adjusted for food intolerance, 12 step guidelines for how to do this in way to minimize symptom flare-ups and cravings are provided by RESHAPE at www.reshapeforhealth.com
• REDUCING your exposure to environmental chemicals (particularly in your home) will reduce the demands being placed on your liver and other detoxification pathways and create a space for naturally detoxifying chemical build-up (Studies by researcher Pamela Reed Gibson show this be most effective for symptom management)
• Eating a lower chemical diet (natural food chemicals and synthetic additives) like the one promoted by RESHAPE and the RPAH allergy Unit.
• Getting additional REST – getting a good nights sleep improves the functioning of everything including your ability to detoxify, if a good nights sleep is not possible yet (an indicator that your overall load is still too high), simply practice mindfulness, the art of being aware of the present moment without concern – according to DEEPAK Chopra in his excellent book on sleep, this can provide many of the same benefits of sleep.
• PACING -Make all changes to your environment and diet slowly in order to minimize detox and withdrawal reactions. If you do not pace you can overwhelm your detox pathways and cause reabsorption of toxins and chemicals and unnecessary injury and symptom intensifications.
Including those deemed safe for most such as colonic irrigation, home coffee enemas, Epsom salt baths (hot water can be too stimulating on a very over taxed and exhausted nervous system and the benefits of Epsom salts have not been substantiated by science). Fasting, lemon weekend detox challenges, chelation therapy, lipid exchange, IV vitamin therapy, sauna therapy and more, particularly if you have severe hypocortisolism- hypoadrenia (low levels of cortisol) and very impaired liver detoxification pathways. According to Pall (and many others) both phase 1 and phase 2 liver detoxification is impaired in people with MCS.
Yanick Says…Detoxification in Individuals with Impaired Enzymatic Detoxification is Contraindicated and Dangerous.
MCS is a disabling, multi-organ syndrome caused by an impaired ability to detoxify chemical toxins. (11,12) According to a recent 2004 International Journal of Epidemiology study, impaired metabolism of toxic chemicals underlies MCS. In this case control study, a gene-gene interaction between enzymes suggested an elevated risk for MCS. (13). These findings parallel other observations of a link between enzyme abnormalities in GulfWar syndrome veterans and in a retrospective case-control analysis reporting cognitive and neurological impairments as symptomatology. (14,15) Clearly, labeling MCS patients as “psychosomatic” is not supported by scientific or clinical evidence. (38)
Source: Hypoadrenia: A causative factor in MCS, Allergies and Impaired Enzymatic Detoxification Dr. Paul Yanick, Jr. Ph.D., N.D. – Board Certified in Integrative Medicine Source: Published in the March 2005 Townsend Letter for Doctors – Revised on 11-20-11 © 2011