More Medical Research Needed; but unfortunately, medical research exploring the condition has been slow. This page hopes to share links on some of the reseach in place….
Some current studies have shown consistent evidence of abnormalities among MCS patients that can be reproduced in laboratory animals. The common findings include problems with the limbic system, the portion of the brain that deals with thought, mood and sensory information.
Another abnormality is blood flow to the cerebral area of the brain. The blood flow is reduced or altered when the offending trigger is introduced.
Other abnormalities found involve an increase of nitrous oxide in the brain and an inability of the liver to detoxify the body of certain chemicals. The immune system of people with MCS is often compromised as well.
- “The Toxicity Data Landscape for Environmental Chemicals” http://ehp.niehs.nih.gov/wp-content/uploads/117/5/ehp.0800168.pdf
- “Brain Dysfunction in Multiple Chemical Sensitivity” http://www.ncbi.nlm.nih.gov/pubmed/19801154
Multiple Chemical Sensitivity (MCS) is a chronic acquired disorder of unknown pathogenesis. The aim of this study was to ascertain whether MCS patients present brain single photon emission computed tomography (SPECT) and psychometric scale changes after a chemical challenge. This procedure was performed with chemical products at non-toxic concentrations in 8 patients diagnosed with MCS and in their healthy controls. In comparison to controls, cases presented basal brain SPECT hypoperfusion in small cortical areas of the right parietal and both temporal and fronto-orbital lobes. After chemical challenge, cases showed hypoperfusion in the olfactory, right and left hippocampus, right parahippocampus, right amygdala, right thalamus, right and left Rolandic and right temporal cortex regions(p<or=0.01). By contrast, controls showed hyperperfusion in the cingulus, right parahippocampus, left thalamus and some cortex regions (p<or=0.01). The clustered deactivation pattern in cases was stronger than in controls (p=0.012) and the clustered activation pattern in controls was higher than in cases (p=0.012). In comparison to controls, cases presented poorer quality of life and neurocognitive function at baseline, and neurocognitive worsening after chemical exposure. Chemical exposure caused neurocognitive impairment, and SPECT brain dysfunction particularly in odor-processing areas, thereby suggesting a neurogenic origin of MCS.
- PMID: 19801154 [PubMed – indexed for MEDLINE]
Biological definition of multiple chemical sensitivity from redox state and cytokine profiling http://www.ncbi.nlm.nih.gov/pubmed/20430047
- “Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats” http://ehp.niehs.nih.gov/wp-content/uploads/122/3/ehp.122-A81.pdf
- “In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project” http://ehp.niehs.nih.gov/0901392/
- Evaluating Potential Response: Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach http://ehp.niehs.nih.gov/wp-content/uploads/122/11/ehp.1307541.alt.pdf or http://ehp.niehs.nih.gov/1307541/
- Dr. Martin L. Pall’s Research
- “MCS and the Workplace; Current Position and Need for Occupational Health Surveillance Protocol (2013) http://issuu.com/armida/docs/workplace_protocol/0
“Transcranial pulsed electromagnetic fields for multiple chemical sensitivity: study protocol for a randomized, double-blind, placebo-controlled trial” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765111/
German Chemical Sensitivity Network http://www.csn-deutschland.de/home.htm
EIR Research Resource http://www.ei-resource.org/research/multiple-chemical-sensitivity-research/
“Two of three patients with multiple chemical sensitivity had less symptoms and secondary hyperalgesia after transcranially applied pulsed electromagnetic fields” http://www.scandinavianjournalpain.com/article/S1877-8860(13)00149-3/abstract
- Toxicogenetics: in search of host susceptibility to environmental toxicants http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170107/
- From the Wiley Online Library, “Unveiling Variability and Uncertainty for Better Science and Decisions on Cancer Risks from Environmental Chemicals” http://onlinelibrary.wiley.com/doi/10.1111/risa.12290/abstract
- European Group on MCS and EMF Research and Treatment http://ehs-mcs.org/ In English: http://www.ehs-mcs.org/en/